Caloric restriction, caloric restriction mimetics, and healthy aging in Okinawa
نویسندگان
چکیده
منابع مشابه
Caloric restriction and its mimetics
Caloric restriction is the most reliable intervention to prevent age-related disorders and extend lifespan. The reduction of calories by 10-30% compared to an ad libitum diet is known to extend the longevity of various species from yeast to rodents. The underlying mechanisms by which the benefits of caloric restriction occur have not yet been clearly defined. However, many studies are being con...
متن کاملCaloric restriction mimetics: metabolic interventions.
Caloric restriction (CR) retards diseases and aging in laboratory rodents and is now being tested in nonhuman primates. One way to apply these findings to human health is to identify and test agents that may mimic critical actions of CR. Panel 2 focused on two outcomes of CR, reduction of oxidative stress and improved glucoregulation, for which candidate metabolic mimics exist. It was recommend...
متن کاملDietary restriction with and without caloric restriction for healthy aging
Caloric restriction is the most effective and reproducible dietary intervention known to regulate aging and increase the healthy lifespan in various model organisms, ranging from the unicellular yeast to worms, flies, rodents, and primates. However, caloric restriction, which in most cases entails a 20-40% reduction of food consumption relative to normal intake, is a severe intervention that re...
متن کامل[Caloric restriction and anti-aging].
エレガンス線虫の寿命は約 3 週間で寿命の遺伝学的解 析に適している.研究室で実験に使っている野生型線虫 (N2)は,20°C で飼育すると,最大寿命が 21 日前後な ので,10 日目には中年特有の表現系を示すことが知ら れている.実際,顕微鏡で観察すると,10 日目には消 化管の周りの脂肪組織が急に黒ずんで目立つようにな る.この症状は脂肪細胞にトリグリセライドの蓄積が増 加するためで,ヒトにおける中年太りの内臓脂肪の蓄積 によく似た症状である. 代表的な長寿線虫,daf-2 変異体は最も遺伝解析が進 んでいる変異体である.daf-2 線虫は耐性幼虫(dauer) になりやすいことから daf(dauer formation,耐性幼虫 化)シリーズの名前が付いている.しかし,運動やリズ ムは正常で,一定温度(高温)で飼育する限り,耐性幼 虫化せずに,寿命は 1.5 倍~2 倍に延...
متن کاملMetabolic reprogramming, caloric restriction and aging.
Caloric restriction (CR) without malnutrition slows the aging process and extends lifespan in diverse species by unknown mechanisms. The inverse linear relationship between calorie intake and lifespan suggests that regulators of energy metabolism are important in the actions of CR. Studies in several species reveal tissue-specific changes in energy metabolism with CR and suggest that metabolic ...
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ژورنال
عنوان ژورنال: Current Opinion in Clinical Nutrition and Metabolic Care
سال: 2013
ISSN: 1363-1950
DOI: 10.1097/mco.0000000000000019